Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07EFM
|
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| Former ID |
DNC002508
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| Drug Name |
Arecoline
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| Drug Type |
Small molecular drug
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| Indication | Parkinson's disease [ICD9: 332; ICD10:G20] | Phase 1 | [1], [2], [3], [4] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C8H13NO2
|
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| InChI |
InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
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| InChIKey |
HJJPJSXJAXAIPN-UHFFFAOYSA-N
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| CAS Number |
CAS 63-75-2
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| PubChem Compound ID | |||||
| PubChem Substance ID |
12315, 105753, 593648, 598409, 5260928, 8151508, 10531347, 11110758, 11110759, 11335985, 11361224, 11362849, 11365411, 11367973, 11372293, 11374438, 11376135, 11462196, 11466430, 11467550, 11483937, 11485999, 11487867, 11491202, 11492625, 11493869, 11537666, 15219310, 26755647, 36538750, 46507231, 47216812, 47291178, 47365235, 47515351, 47515352, 47736525, 47959789, 48035165, 48185035, 48334535, 48415577, 49698472, 49997631, 50110935, 50110936, 53789882, 57321212, 78997792, 85209508
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| Target and Pathway | |||||
| Target(s) | Muscarinic acetylcholine receptor M1 | Target Info | Inhibitor | [5] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| PI3K-Akt signaling pathway | |||||
| Cholinergic synapse | |||||
| Regulation of actin cytoskeleton | |||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||||
| Reactome | Muscarinic acetylcholine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| Regulation of Actin Cytoskeleton | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor. Chin J Physiol. 2000 Mar 31;43(1):23-8. | ||||
| REF 2 | M1 receptor activation is a requirement for arecoline analgesia. Farmaco. 2001 May-Jul;56(5-7):383-5. | ||||
| REF 3 | Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits. Chin J Physiol. 2004 Jun 30;47(2):89-94. | ||||
| REF 4 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 296). | ||||
| REF 5 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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