Drug General Information
Drug ID
D07EEN
Former ID
DCL000870
Drug Name
Lixivaptan
Synonyms
VPA985; Lixivaptan [USAN:INN]; VPA-985; Lixivaptan (USAN/INN); N-[3-chloro-4-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepine-5-carbonyl)phenyl]-5-fluoro-2-methylbenzamide
Drug Type
Small molecular drug
Indication Euvolemic hyponatremia; Hypervolemic hyponatremia [ICD9: 276.1; ICD10:E87.1] Phase 3 [537063], [539415]
Congestive heart failure [ICD9: 428; ICD10:I50] Phase 2 [537063], [539415]
Company
Wyeth-Ayerst; Cardiokine
Structure
Download
2D MOL

3D MOL

Formula
C27H21ClFN3O2
InChI
InChI=1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)
InChIKey
PPHTXRNHTVLQED-UHFFFAOYSA-N
CAS Number
CAS 168079-32-1
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Antagonist [536372]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorption
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 537063Physical state of kappa-carrageenan modulates the mode of action of kappa-carrageenase from Pseudoalteromonas carrageenovora. Biochem J. 2009 May 1;419(3):545-53.
Ref 539415(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2238).
Ref 536372Emerging drugs for acute and chronic heart failure: current and future developments. Expert Opin Emerg Drugs. 2007 Mar;12(1):75-95.

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