Drug General Information |
Drug ID |
D07DLA
|
Former ID |
DIB003500
|
Drug Name |
ISF-402
|
Synonyms |
Urinary tetrapeptide (diabetes), Monash University/International Diabetes Institute/Pallane; Urinary tetrapeptide (diabetes), Monash University/International Diabetes Institute/Dia-B Tech Ltd
|
Indication |
Type 2 diabetes [ICD9: 250; ICD10:E11]
|
Phase 1 |
[1]
|
Company |
Dia-B Tech
|
Structure |
|
Download
2D MOL
3D MOL
|
Canonical SMILES |
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(=O<br />)O)[C@H](O)C)Cc1c[nH]cn1)C(C)C
|
Target and Pathway |
Target(s) |
Insulin receptor |
Target Info |
Modulator |
[2]
|
KEGG Pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
cGMP-PKG signaling pathway
|
HIF-1 signaling pathway
|
FoxO signaling pathway
|
PI3K-Akt signaling pathway
|
AMPK signaling pathway
|
Adherens junction
|
Insulin signaling pathway
|
Ovarian steroidogenesis
|
Type II diabetes mellitus
|
Non-alcoholic fatty liver disease (NAFLD)
|
Aldosterone-regulated sodium reabsorption
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
PANTHER Pathway
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
PI3 kinase pathway
|
Pathway Interaction Database
|
Insulin Pathway
|
Signaling events mediated by PTP1B
|
Signaling events mediated by TCPTP
|
Insulin-mediated glucose transport
|
PathWhiz Pathway
|
Insulin Signalling
|
Leucine Stimulation on Insulin Signaling
|
Reactome
|
IRS activation
|
Signal attenuation
|
Insulin receptor signalling cascade
|
Insulin receptor recycling
|
WikiPathways
|
DNA Damage Response (only ATM dependent)
|
Insulin Signaling
|
Nanoparticle triggered autophagic cell death
|
AGE/RAGE pathway
|
Signaling by Insulin receptor
|
Folate Metabolism
|
Type II diabetes mellitus
|
Vitamin B12 Metabolism
|
Selenium Micronutrient Network
|
AMPK Signaling
|
References |
REF 1 | Clinical pipeline report, company report or official report of Dia-B Tech. |
---|
REF 2 | Ability of GHTD-amide and analogs to enhance insulin activity through zinc chelation and dispersal of insulin oligomers. Peptides. 2009 Jun;30(6):1088-97. |