Drug Information

Drug General Information
Drug ID
D07DIX
Former ID
DIB000025
Drug Name
ALO-1567
Synonyms
AL01567; 2-Fluorospiro[9H-fluorene-9,4'-imidazolidine]-2',5'-dione
Drug Type
Small molecular drug
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Phase 1 [530034]
Structure
Download
2D MOL

3D MOL
Formula
C15H9FN2O2
Canonical SMILES
C1=CC=C2C(=C1)C3=C(C24C(=O)NC(=O)N4)C=C(C=C3)F
InChI
1S/C15H9FN2O2/c16-8-5-6-10-9-3-1-2-4-11(9)15(12(10)7-8)13(19)17-14(20)18-15/h1-7H,(H2,17,18,19,20)
InChIKey
JRGBXEJDIMXJAP-UHFFFAOYSA-N
CAS Number
CAS 97677-19-5
PubChem Compound ID
119155
PubChem Substance ID
10238368, 14799197, 29300102, 51427836, 57339353, 103118569, 103165585, 103922826, 104407663, 117510912, 126434266, 128316037, 135075295, 139060528, 142773097, 227435259
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [530034], [551871]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 530034Metabolism of the aldose reductase inhibitor ALO1567 in man. Br J Clin Pharmacol. 1991 Aug;32(2):221-7.
Ref 530034Metabolism of the aldose reductase inhibitor ALO1567 in man. Br J Clin Pharmacol. 1991 Aug;32(2):221-7.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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