Drug Information

Drug General Information
Drug ID
D07BBR
Former ID
DNC005406
Drug Name
9-Fluoro-6H,11H-indeno[1,2-c]isoquinolin-5-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527674]
Structure
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2D MOL

3D MOL
Formula
C16H10FNO
Canonical SMILES
C1C2=C(C=CC(=C2)F)C3=C1C4=CC=CC=C4C(=O)N3
InChI
1S/C16H10FNO/c17-10-5-6-11-9(7-10)8-14-12-3-1-2-4-13(12)16(19)18-15(11)14/h1-7H,8H2,(H,18,19)
InChIKey
YZRNXEMHDKXRRA-UHFFFAOYSA-N
PubChem Compound ID
25190932
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [527674]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 527674J Med Chem. 2005 Aug 11;48(16):5100-3.Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.
Ref 527674J Med Chem. 2005 Aug 11;48(16):5100-3.Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.

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