Drug General Information
Drug ID	D06ZXH
Former ID	DIB016192
Drug Name	PHN-131
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Phase 2/3	[548815]
Company	PhytoHealth Corp
Structure		Download 2D MOL 3D MOL
Formula	C21H28ClNO4
Canonical SMILES	C1CC(C1)CN2CCC34C5C(CCC3(C2CC6=C4C(=C(C=C6)O)O5)O)O.Cl
InChIKey	YZLZPSJXMWGIFH-BCXQGASESA-N
PubChem Compound ID	5360733
PubChem Substance ID	7847908, 10321398, 11653782, 12013401, 14756670, 39384041, 49993184, 56463337, 57362031, 78556438, 92125102, 103771115, 103913893, 134994351, 162188822, 175268953, 175611741, 179149036, 223897817, 226426224, 241042425, 252160269, 252402062
Target and Pathway
Target(s)	Kappa-type opioid receptor	Target Info	Agonist	[533353]
KEGG Pathway	Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Opioid prodynorphin pathway
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548815	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029095)
Ref 533353	Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic. J Pharmacol Exp Ther. 1988 Jan;244(1):391-402.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.