Drug Information

Drug General Information
Drug ID
D06ZII
Former ID
DAP000933
Drug Name
Eszopiclone
Synonyms
Esopiclone; Estorra; Lunesta; Lunivia; Zopiclone; Estorra (TN); Eszopiclone [USAN:INN]; KS-1055; Lunesta (TN); SEP-0227018; SEP-0227108; SEP-190; SEP-225441; Eszopiclone (JAN/USAN/INN); [(7S)-6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate; (+)-(5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate; (+)-Zopiclone; (5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate; (5S)-6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate; (5S)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate; (S)-Zopiclone; (plus)-Zopiclone; 1-Piperazinecarboxylic acid, 4-methyl-, (5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester
Drug Type
Small molecular drug
Indication Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] Approved [536647], [542452]
Therapeutic Class
Hypnotics and Sedatives
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C17H17ClN6O3
InChI
InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3/t16-/m0/s1
InChIKey
GBBSUAFBMRNDJC-INIZCTEOSA-N
CAS Number
CAS 138729-47-2
PubChem Compound ID
969472
PubChem Substance ID
8719708, 12015386, 14927588, 17396794, 25819909, 26612818, 29215492, 44256005, 46505809, 49666409, 50070163, 50070571, 50071326, 57408900, 61128015, 75503740, 87246620, 89736090, 92714227, 103558705, 104170161, 110105491, 117478867, 121362188, 121362390, 125169642, 126592991, 126627684, 126629616, 126655556, 131298420, 131378756, 134221729, 135114014, 135696725, 137002949, 141949765, 144205286, 152035015, 160963748, 162957823, 164196530, 164832496, 170465445, 172080786, 175265884, 175271194, 175610981, 178104001, 179149892
SuperDrug ATC ID
N05CF04
Target and Pathway
Target(s) Peripheral-type benzodiazepine receptor Target Info Agonist [536166], [536625]
KEGG Pathway Neuroactive ligand-receptor interaction
HTLV-I infection
References
Ref 536647Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62.
Ref 542452(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7429).
Ref 536166Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
Ref 536625New hypnotics: perspectives from sleep physiology. Vertex. 2007 Jul-Aug;18(74):294-9.

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