Drug General Information
Drug ID	D06UVO
Former ID	DIB014433
Drug Name	DuP-654
Drug Type	Small molecular drug
Indication	Pruritus [ICD9: 698; ICD10:L29]		Discontinued in Phase 2	[545553]
Company	Bristol-Myers Squibb Pharma Co
Structure		Download 2D MOL 3D MOL
Formula	C17H14O
Canonical SMILES	c1(c(Cc2ccccc2)ccc2c1cccc2)O
CAS Number	CAS 36441-32-4
PubChem Compound ID	160268
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[534020]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 545553	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003690)
Ref 534020	The lipoxygenase inhibitor 2-phenylmethyl-1-naphthol (DuP 654) is a 12(S)-hydroxyeicosatetraenoic acid receptor antagonist in the human epidermal cell line SCL-II. Skin Pharmacol. 1993;6(2):148-51.

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