Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06UVO
|
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| Former ID |
DIB014433
|
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| Drug Name |
DuP-654
|
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| Drug Type |
Small molecular drug
|
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| Indication | Pruritus [ICD9: 698; ICD10:L29] | Discontinued in Phase 2 | [1] | ||
| Company |
Bristol-Myers Squibb Pharma Co
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H14O
|
||||
| Canonical SMILES |
c1(c(Cc2ccccc2)ccc2c1cccc2)O
|
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| CAS Number |
CAS 36441-32-4
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Arachidonate 5-lipoxygenase | Target Info | Inhibitor | [2] | |
| BioCyc Pathway | Aspirin-triggered lipoxin biosynthesis | ||||
| Resolvin D biosynthesis | |||||
| Leukotriene biosynthesis | |||||
| Lipoxin biosynthesis | |||||
| Aspirin triggered resolvin D biosynthesis | |||||
| Aspirin triggered resolvin E biosynthesis | |||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Toxoplasmosis | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Vitamin D Receptor Pathway | ||||
| Arachidonic acid metabolism | |||||
| Eicosanoid Synthesis | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003690) | ||||
| REF 2 | The lipoxygenase inhibitor 2-phenylmethyl-1-naphthol (DuP 654) is a 12(S)-hydroxyeicosatetraenoic acid receptor antagonist in the human epidermal cell line SCL-II. Skin Pharmacol. 1993;6(2):148-51. | ||||
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