Drug General Information
Drug ID
D06UNX
Former ID
DNC002716
Drug Name
Verdoheme
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551391]
Structure
Download
2D MOL

3D MOL

Formula
C30H29FeN4O3+3
Canonical SMILES
CC1=C(C2=[O+]C3=NC(=CC4=C(C(=C([N-]4)C=CN=C(C=C1[N-]2)C<br />(=C)C)CCC(=O)O)C)C(=C3C)C=C)C=C.[Fe+4]
InChI
1S/C30H30N4O3.Fe/c1-8-20-19(7)29-34-27(20)15-25-18(6)22(10-11-28(35)36)23(32-25)12-13-31-24(16(3)4)14-26-17(5)21(9-2)30(33-26)37-29;/h8-9,12-15H,1-3,10-11H2,4-7H3,(H2-,31,32,33,34,35,36);/q;+4/p-1
InChIKey
QNHRNHLUNLNYAK-UHFFFAOYSA-M
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Heme oxygenase Target Info Inhibitor [551391]
BioCyc Pathway Heme degradation
KEGG Pathway Porphyrin and chlorophyll metabolism
HIF-1 signaling pathway
Mineral absorption
MicroRNAs in cancer
Pathway Interaction Database Validated transcriptional targets of AP1 family members Fra1 and Fra2
HIF-1-alpha transcription factor network
PathWhiz Pathway Porphyrin Metabolism
Reactome Iron uptake and transport
WikiPathways Oxidative Stress
Transcriptional activation by NRF2
NRF2 pathway
Nuclear Receptors Meta-Pathway
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January

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