Drug Information

Drug General Information
Drug ID
D06SJZ
Former ID
DIB001705
Drug Name
XB-947
Synonyms
XR-469R; (+)-2(R)-[4-(7-Chloroquinoxalin-2-yloxy)phenoxy]propionic acid sodium salt; (R)-(+)-XK-469
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [544092]
Structure
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2D MOL

3D MOL
Formula
C18H15ClN2O4
Canonical SMILES
CC(C(=O)OC)OC1=CC=C(C=C1)OC2=CN=C3C=CC(=CC3=N2)Cl
InChI
1S/C18H15ClN2O4/c1-11(18(22)23-2)24-13-4-6-14(7-5-13)25-17-10-20-15-8-3-12(19)9-16(15)21-17/h3-11H,1-2H3
InChIKey
NPUWJNOFOGQLSR-UHFFFAOYSA-N
PubChem Compound ID
157156
PubChem Substance ID
46232809, 50022271, 80116266, 103234459, 113436759, 117481308, 125742439, 128737254, 135113808, 162797710, 234343331
Target and Pathway
Target(s) DNA topoisomerase II, beta isozyme Target Info Modulator [544018]
PANTHER Pathway DNA replication
References
Ref 544092A phase I and pharmacokinetic study of the quinoxaline antitumour Agent R(+)XK469 in patients with advanced solid tumours. Eur J Cancer. 2008 August; 44(12): 1684-1692.
Ref 544018XK469, a selective topoisomerase IIbeta poison. Proc Natl Acad Sci U S A. 1999 October 12; 96(21): 12168-12173.

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