TTD | Drug: D06SAT

Drug General Information
Drug ID	D06SAT
Former ID	DIB002839
Drug Name	HZ-166
Synonyms	Benzodiazepine derivatives (neuropathic pain); HZ-166; Benzodiazepine derivatives (neuropathic pain), Addiction Therapeutix
Indication	Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0]		Investigative	[543814]
Company	University of Wisconsin-Milwaukee
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1c(cc2c(c1)n1c(CN=C2c2ccccn2)c(nc1)C(=O)OCC)C#C
Target and Pathway
Target(s)	GABA A receptor	Target Info	Modulator	[543814]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
Reactome	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 543814	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
Ref 543814	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).

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Drug Information