Drug General Information
Drug ID	D06QRW
Former ID	DIB003873
Drug Name	Lazabemide
Synonyms	Lazabemine; Pakio; Tempium; Ro-19-6327; Ro-41-3776; Ro-19-6327/000
Drug Type	Small molecular drug
Indication	Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3]		Discontinued in Phase 3	[541750], [545650]
Company	Roche Holding AG
Structure		Download 2D MOL 3D MOL
Formula	C8H10ClN3O
InChI	InChI=1S/C8H10ClN3O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10/h1-2,5H,3-4,10H2,(H,11,13)
InChIKey	JZXRLKWWVNUZRB-UHFFFAOYSA-N
PubChem Compound ID	71307
PubChem Substance ID	7980091, 8194561, 15220005, 43127665, 47206517, 50064090, 50112873, 50460487, 57318127, 92729659, 103183900, 103831836, 103938836, 104350168, 117465703, 126424309, 128351763, 132555187, 134343054, 135028045, 137239417, 139290484, 139640715, 164814824, 178103253, 179149503, 184545911, 198970494, 224982470, 226493370, 252216705, 252351209, 252428934
Target and Pathway
Target(s)	Amine oxidase [flavin-containing] B	Target Info	Inhibitor	[534569]
BioCyc Pathway	Superpathway of tryptophan utilization
	Tryptophan degradation via tryptamine
	Dopamine degradation
	Putrescine degradation III
	Noradrenaline and adrenaline degradation
KEGG Pathway	Glycine, serine and threonine metabolism
	Arginine and proline metabolism
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	Tryptophan metabolism
	Drug metabolism - cytochrome P450
	Metabolic pathways
	Serotonergic synapse
	Dopaminergic synapse
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	5-Hydroxytryptamine degredation
	Dopamine receptor mediated signaling pathway
Pathway Interaction Database	Alpha-synuclein signaling
WikiPathways	Tryptophan metabolism
	Dopamine metabolism
	Phase 1 - Functionalization of compounds
References
Ref 541750	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6640).
Ref 545650	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004032)
Ref 534569	The activity of MAO A and B in rat renal cells and tubules. Life Sci. 1998;62(8):727-37.

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