Drug Information

Drug General Information
Drug ID
D06QKW
Former ID
DIB019143
Drug Name
cirazoline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468213]
Structure
Download
2D MOL
Formula
C13H16N2O
InChI
InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
InChIKey
YAORIDZYZDUZCM-UHFFFAOYSA-N
PubChem Compound ID
2765
PubChem Substance ID
4816529, 7978952, 8151786, 11110893, 11113761, 11120292, 11120780, 11121268, 11121651, 11122131, 11362720, 11365282, 11367844, 11370711, 11370712, 11373445, 11376006, 12012735, 14993968, 26751944, 26751945, 29221920, 47364966, 47440014, 48334242, 49979380, 50104620, 50104621, 50891172, 57321445, 85209513, 85788752, 90341611, 92098522, 92308777, 92310002, 99300914, 99302434, 103175726, 103936642, 104171120, 104301544, 124749647, 124879511, 124879512, 124879513, 124879514, 124879515, 129767852, 135027726
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Agonist [533826]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 468213(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 515).
Ref 533826Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.