Drug General Information
Drug ID	D06QEN
Former ID	DNC012114
Drug Name	7-Methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534126]
Structure		Download 2D MOL 3D MOL
Formula	C11H11N5
Canonical SMILES	CN1C=CC2=C1C=CC3=C2C(=NC(=N3)N)N
InChI	1S/C11H11N5/c1-16-5-4-6-8(16)3-2-7-9(6)10(12)15-11(13)14-7/h2-5H,1H3,(H4,12,13,14,15)
InChIKey	WSISEVQVCUARDZ-UHFFFAOYSA-N
PubChem Compound ID	467889
Target and Pathway
Target(s)	Dihydrofolate reductase	Target Info	Inhibitor	[534126]
PathWhiz Pathway	Folate Metabolism
	Pterine Biosynthesis
Reactome	E2F mediated regulation of DNA replication
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	Metabolism of folate and pterines
	G1/S-Specific Transcription
References
Ref 534126	J Med Chem. 1996 Feb 16;39(4):892-903.High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Ref 534126	J Med Chem. 1996 Feb 16;39(4):892-903.High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.