Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06PZN
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| Former ID |
DNC000959
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| Drug Name |
Mosapride
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Phase 4 | [1], [2] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C21H25ClFN3O3
|
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| InChI |
InChI=1S/C21H25ClFN3O3/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27)
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| InChIKey |
YPELFRMCRYSPKZ-UHFFFAOYSA-N
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| CAS Number |
CAS 112885-41-3
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| PubChem Compound ID | |||||
| PubChem Substance ID |
10238548, 14856046, 29216210, 29300427, 47434920, 48254040, 49875381, 50110109, 53346072, 57339567, 85209635, 90452581, 92720568, 93374710, 93626124, 96024924, 103250420, 103923914, 104408671, 117843401, 125324809, 125338080, 126607121, 126619873, 126648433, 126666115, 129828067, 131294814, 131294815, 131813325, 134340239, 135134188, 135650625, 135683234, 136373748, 137249282, 137541651, 143504192, 144108846, 160809785, 162035093, 162181032, 163088239, 164035874, 164175206, 164814860, 166236538, 172090760, 172842270, 174006284
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 4 receptor | Target Info | Agonist | [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT4 type receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT02056405) Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery. U.S. National Institutes of Health. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 242). | ||||
| REF 3 | The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):125-37. Epub 2008 Apr 16. | ||||
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