Drug Information

Drug General Information
Drug ID
D06PNU
Former ID
DNC006335
Drug Name
Tic-D-Phe-Arg-2-Nal-NHCH3
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527941]
Structure
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2D MOL

3D MOL
Formula
C39H46N8O4
Canonical SMILES
CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)NC(=O)C(CCCN=C(N)N)NC(=O)<br />C(CC3=CC=CC=C3)NC(=O)C4CC5=CC=CC=C5CN4
InChI
1S/C39H46N8O4/c1-42-35(48)33(22-26-17-18-27-12-5-6-13-28(27)20-26)46-36(49)31(16-9-19-43-39(40)41)45-38(51)34(21-25-10-3-2-4-11-25)47-37(50)32-23-29-14-7-8-15-30(29)24-44-32/h2-8,10-15,17-18,20,31-34,44H,9,16,19,21-24H2,1H3,(H,42,48)(H,45,51)(H,46,49)(H,47,50)(H4,40,41,43)/t31-,32-,33-,34+/m0/s1
InChIKey
MCHDZFRIUNRJGL-GZXHTMMISA-N
PubChem Compound ID
44409257
Target and Pathway
Target(s) Melanocyte stimulating hormone receptor Target Info Inhibitor [527941]
Melanocortin-4 receptor Target Info Inhibitor [527941]
Melanocortin-3 receptor Target Info Inhibitor [527941]
KEGG Pathway Neuroactive ligand-receptor interaction
Melanogenesishsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Pathway Interaction Database Syndecan-3-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (s) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 527941Bioorg Med Chem Lett. 2006 Mar 15;16(6):1721-5. Epub 2005 Dec 20.Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists.
Ref 527941Bioorg Med Chem Lett. 2006 Mar 15;16(6):1721-5. Epub 2005 Dec 20.Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists.

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