Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06ODM
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| Former ID |
DCL000303
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| Drug Name |
Talsaclidine fumarate
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| Synonyms |
Wal 2014 FU; Talsaclidine fumarate (USAN); (E)-but-2-enedioic acid; 1-Azabicyclo(2.2.2)octane, 3-(2-propynyloxy)-, (R)-, (E)-2-butenedioate (1:1); 3-(2-Propynyloxy)-1-azabicyclo(2.2.2)octane 2-butenedioate; 3-prop-2-ynoxy-1-azabicyclo[2.2.2]octane
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Discontinued in Phase 2 | [1] | ||
| Company |
Boehringer
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| Structure |
|
Download2D MOL |
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| Formula |
C14H19NO5
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| Canonical SMILES |
C#CCOC1CN2CCC1CC2.C(=CC(=O)O)C(=O)O
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| InChI |
1S/C10H15NO.C4H4O4/c1-2-7-12-10-8-11-5-3-9(10)4-6-11;5-3(6)1-2-4(7)8/h1,9-10H,3-8H2;1-2H,(H,5,6)(H,7,8)/b;2-1+
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| InChIKey |
SBCXBWBXWKVIFK-WLHGVMLRSA-N
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| CAS Number |
CAS 147025-54-5
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Muscarinic acetylcholine receptor M1 | Target Info | Agonist | [2], [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| PI3K-Akt signaling pathway | |||||
| Cholinergic synapse | |||||
| Regulation of actin cytoskeleton | |||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||||
| Reactome | Muscarinic acetylcholine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| Regulation of Actin Cytoskeleton | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001956) | ||||
| REF 2 | Memory-related task performance by aged rhesus monkeys administered the muscarinic M(1)-preferring agonist, talsaclidine. Psychopharmacology (Berl). 2002 Jul;162(3):292-300. Epub 2002 May 29. | ||||
| REF 3 | Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. Epub 2009 Jan 11. | ||||
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