Drug Information

Drug General Information
Drug ID
D06NTB
Former ID
DNC004168
Drug Name
3-(4-Methyl-piperidin-1-ylmethyl)-1H-indole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534131]
Structure
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2D MOL

3D MOL
Formula
C15H20N2
Canonical SMILES
CC1CCN(CC1)CC2=CNC3=CC=CC=C32
InChI
1S/C15H20N2/c1-12-6-8-17(9-7-12)11-13-10-16-15-5-3-2-4-14(13)15/h2-5,10,12,16H,6-9,11H2,1H3
InChIKey
DGCGMYNLCDVYMB-UHFFFAOYSA-N
PubChem Compound ID
30438
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Inhibitor [534131]
D(2) dopamine receptor Target Info Inhibitor [534131]
D(3) dopamine receptor Target Info Inhibitor [534131]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
GPCRs, Other
References
Ref 534131J Med Chem. 1996 May 10;39(10):1941-2.3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
Ref 534131J Med Chem. 1996 May 10;39(10):1941-2.3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

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