Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06MPF
|
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| Former ID |
DIB009200
|
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| Drug Name |
Sch-40120
|
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| Drug Type |
Small molecular drug
|
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| Indication | Pruritus [ICD9: 698; ICD10:L29] | Terminated | [1] | ||
| Company |
Schering-Plough Corp
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C18H15ClN2O
|
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| Canonical SMILES |
n1(c2c(c(=O)c3c1CCCC3)cccn2)c1cc(Cl)ccc1
|
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| CAS Number |
CAS 110545-79-4
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Arachidonate 5-lipoxygenase | Target Info | Modulator | [2] | |
| BioCyc Pathway | Aspirin-triggered lipoxin biosynthesis | ||||
| Resolvin D biosynthesis | |||||
| Leukotriene biosynthesis | |||||
| Lipoxin biosynthesis | |||||
| Aspirin triggered resolvin D biosynthesis | |||||
| Aspirin triggered resolvin E biosynthesis | |||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Toxoplasmosis | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Vitamin D Receptor Pathway | ||||
| Arachidonic acid metabolism | |||||
| Eicosanoid Synthesis | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003693) | ||||
| REF 2 | Actions of a 5-lipoxygenase inhibitor, Sch 40120, on acute inflammatory responses. J Pharmacol Exp Ther. 1992 Aug;262(2):721-8. | ||||
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