Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06MNF
|
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| Former ID |
DCL000915
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| Drug Name |
Pardoprunox
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| Synonyms |
Pardoprunox (USAN/INN); 7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one; 7-(4-methylpiperazin-1-yl)-3H-benzooxazol-2-one
|
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| Drug Type |
Small molecular drug
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| Indication | Advanced stage Parkinson's disease [ICD9: 332; ICD10:F02.3, G20] | Phase 2 | [1] | ||
| Company |
Solvay
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C12H15N3O2
|
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| Canonical SMILES |
CN1CCN(CC1)C2=CC=CC3=C2OC(=O)N3
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| InChI |
1S/C12H15N3O2/c1-14-5-7-15(8-6-14)10-4-2-3-9-11(10)17-12(16)13-9/h2-4H,5-8H2,1H3,(H,13,16)
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| InChIKey |
YVPUUUDAZYFFQT-UHFFFAOYSA-N
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| CAS Number |
CAS 269718-84-5
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | D(2) dopamine receptor | Target Info | Agonist | [1] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| References | |||||
| REF 1 | Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. | ||||
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