Drug Information

Drug General Information
Drug ID
D06KZL
Former ID
DCL001102
Drug Name
AG140699
Indication Melanoma [ICD9: 172; ICD10:C43] Phase 2 [551838]
Therapeutic Class
Anticancer Agents
Company
Pfizer
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [536077]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 551838Critical Care Nephrology, Claudio Ronco,Rinaldo Bellomo,John A. Kellum. Page(444).
Ref 536077Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40.

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