Drug General Information
Drug ID	D06KFR
Former ID	DIB003528
Drug Name	RP-73163
Drug Type	Small molecular drug
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Terminated	[545520]
Company	Rhone-Poulenc SA
Structure		Download 2D MOL 3D MOL
Formula	C26H30N4OS
Canonical SMILES	c1(nc(c([nH]1)c1ccccc1)c1ccccc1)[S@@](=O)CCCCCn1nc(cc1C<br />)C
CAS Number	CAS 154461-48-0
PubChem Compound ID	44356696
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[534282]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 545520	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003588)
Ref 534282	Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor (RP 73163) in animals fed diets low in cholesterol. Biochem Pharmacol. 1996 Oct 25;52(8):1177-86.

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