Drug General Information
Drug ID	D06JDW
Former ID	DNC014517
Drug Name	N-(3-(aminomethyl)-benzyl)acetamidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531201]
Structure		Download 2D MOL
Formula	C10H15N3
Canonical SMILES	CC(=NCC1=CC(=CC=C1)CN)N
InChI	1S/C10H15N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5H,6-7,11H2,1H3,(H2,12,13)
InChIKey	RODUKNYOEVZQPR-UHFFFAOYSA-N
PubChem Compound ID	1433
Target and Pathway
Target(s)	Nitric-oxide synthase, brain	Target Info	Inhibitor	[531201]
	Nitric oxide synthase, inducible	Target Info	Inhibitor	[531201]
BioCyc Pathway	Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
KEGG Pathway	Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	Phagosome
	Circadian entrainment
	Long-term depression
	Salivary secretion
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)hsa00220:Arginine biosynthesis
	HIF-1 signaling pathway
	Peroxisome
	Salmonella infection
	Pertussis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Amoebiasis
	Tuberculosis
	Pathways in cancer
	Small cell lung cancer
NetPath Pathway	EGFR1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
	IL2 Signaling Pathway
PANTHER Pathway	CCKR signaling map ST
Pathway Interaction Database	IL12-mediated signaling events
	Alpha9 beta1 integrin signaling events
	ATF-2 transcription factor network
	IL23-mediated signaling events
	Signaling mediated by p38-alpha and p38-beta
	HIF-1-alpha transcription factor network
PathWhiz Pathway	Arginine and Proline Metabolism
Reactome	ROS production in response to bacteria
	Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
	Nitric oxide stimulates guanylate cyclase
WikiPathways	Monoamine Transport
	Myometrial Relaxation and Contraction Pathways
	Amyotrophic lateral sclerosis (ALS)
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Alzheimers Disease
	Effects of Nitric Oxide
	Serotonin Transporter ActivityWP619:Type II interferon signaling (IFNG)
	AGE/RAGE pathway
References
Ref 531201	Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. Epub 2010 Sep 17.N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.
Ref 531201	Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. Epub 2010 Sep 17.N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.

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