Drug Information

Drug General Information
Drug ID
D06IME
Former ID
DIB000716
Drug Name
CCX-140
Synonyms
CCX-140-B; CCR2 receptor antagonist (inflammation/multiple sclerosis/metabolic disease), ChemoCentryx; CCR2 receptor antagonist (inflammation/multiple sclerosis/metabolic disease/chronic kidney disease), ChemoCentryx
Indication Diabetic nephropathy [ICD9: 250.4; ICD10:E11.21] Phase 2 [547696]
Company
Chemocentryx
Structure
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2D MOL

3D MOL
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Antagonist [533233]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 547696Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018498)
Ref 533233Present and future in the treatment of diabetic kidney disease. J Diabetes Res. 2015;2015:801348.

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