Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06HXC
|
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| Former ID |
DNC001043
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| Drug Name |
NPY-1 antagonist
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| Drug Type |
Small molecular drug
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| Indication | Eating disorders reduction in food intake obesity anxiety [ICD9: 307.5; ICD10:F50] | Investigative | [1] | ||
| Company |
Pfizer
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C30H35N5O3
|
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| Canonical SMILES |
C1CC(OC1)CNC(=O)NC(=NCC2=CC(=CC=C2)CNC(=O)C(CC3=CC=CC=C<br />3)C4=CC=CC=C4)N
|
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| InChI |
1S/C30H35N5O3/c31-29(35-30(37)34-21-26-15-8-16-38-26)33-20-24-12-7-11-23(17-24)19-32-28(36)27(25-13-5-2-6-14-25)18-22-9-3-1-4-10-22/h1-7,9-14,17,26-27H,8,15-16,18-21H2,(H,32,36)(H4,31,33,34,35,37)
|
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| InChIKey |
BSGMHDGHMYUSDC-UHFFFAOYSA-N
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| CAS Number |
CAS 262418-00-8
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Neuropeptide Y receptor type 1 | Target Info | Antagonist | [2] | |
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| NetPath Pathway | FSH Signaling Pathway | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| Endothelin Pathways | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Neuropeptide Y receptor antagonists. IDrugs. 2001 Aug;4(8):920-7. | ||||
| REF 2 | Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. | ||||
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