Drug General Information
Drug ID	D06GNF
Former ID	DIB010651
Drug Name	TS-022
Synonyms	Prostaglandin derivative (topical, dermatitis), Taisho
Indication	Atopic dermatitis [ICD9: 691.8, 692.9; ICD10:L00-L99]		Phase 2	[522686]
Company	Taisho Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	[C@@H]1([C@@H]([C@H]([C@@H](C1)Cl)CCCCSCC(=O)O)C#C[C@H]<br />(C1CCCCC1)O)O
CAS Number	CAS 170730-17-3
Target and Pathway
Target(s)	Prostaglandin D2 receptor	Target Info	Agonist	[528554]
KEGG Pathway	Neuroactive ligand-receptor interaction
Pathway Interaction Database	Thromboxane A2 receptor signaling
PathWhiz Pathway	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome	Prostanoid ligand receptors
	G alpha (s) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522686	ClinicalTrials.gov (NCT00914186) Study of TS-022 in Adult Patients With Atopic Dermatitis With Pruritus (POC). U.S. National Institutes of Health.
Ref 528554	Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. Eur J Pharmacol. 2007 Feb 5;556(1-3):207-14. Epub 2006 Nov 3.

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