Drug Information

Drug General Information
Drug ID
D06GDY
Former ID
DAP000463
Drug Name
Paroxetine
Synonyms
Aropax; Casbol; Frosinor; Motivan; Paroxetina; Paroxetinum; PaxPar; Paxetil; Paxil; Pexeva; Seroxat; Paroxetine Hcl; Paxil CR;Seroxat CR; BRL 29060; FG 7051; [3H]Paroxetine; BRL-29060; FG-7051; Paroxetina [INN-Spanish]; Paroxetine (TN); Paroxetinum [INN-Latin]; Paxil (TN); Seroxat (TN); NNC-20-7051; Paroxetine (USP/INN); Paroxetine [USAN:INN:BAN]; (-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine; (-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-methylenedioxy)phenoxy)methyl)piperidine; (-)-Paroxetine; (-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)piperidine; (-)-trans-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]-piperidine; (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine; (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine; (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine; (3S-trans)-3-[(1,3-Benzodioxol-5-yl-oxy)methyl]-4-(4-fluorophenyl)piperidine; 3-(Benzo[1,3]Dioxol-5-Yl-Oxymethyl)-4-(4-Fluoro-Phenyl)-Piperidine Hydrochloride
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Approved [468019], [537349]
Therapeutic Class
Antidepressants
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C19H20FNO3
InChI
InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1/i5T
InChIKey
AHOUBRCZNHFOSL-RXMHWKDRSA-N
CAS Number
CAS 61869-08-7
PubChem Compound ID
53316721
PubChem Substance ID
124956274, 160857041, 178101282, 223868935
ChEBI ID
ChEBI:7936
SuperDrug ATC ID
N06AB05
SuperDrug CAS ID
cas=061869087
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Modulator [556264]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 468019(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4790).
Ref 537349Emerging drug therapies in Huntington's disease. Expert Opin Emerg Drugs. 2009 Jun;14(2):273-97.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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