Drug Information

Drug General Information
Drug ID
D06FLP
Former ID
DNCL001699
Drug Name
AMG 811
Indication Discoid lupus erythematosus; Systemic lupus erythematosus [ICD9: 695.4, 710; ICD10:L93.0, M32] Phase 1 [548727]
Company
Amgen
Target and Pathway
Target(s) Interferon gamma Target Info Modulator [532955]
KEGG Pathway Proteasome
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Regulation of autophagy
TGF-beta signaling pathway
Osteoclast differentiation
Antigen processing and presentation
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Type I diabetes mellitus
Salmonella infection
Leishmaniasis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Measles
Influenza A
Herpes simplex infection
Epstein-Barr virus infection
Inflammatory bowel disease (IBD)
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
NetPath Pathway IL1 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interferon-gamma signaling pathway
Pathway Interaction Database IL27-mediated signaling events
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
SHP2 signaling
Regulation of Telomerase
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
IFN-gamma pathway
ATF-2 transcription factor network
AP-1 transcription factor network
IL23-mediated signaling events
PDGFR-alpha signaling pathway
Calcium signaling in the CD4+ TCR pathway
Downstream signaling in na&#xef
IL12 signaling mediated by STAT4
Reactome Interferon gamma signaling
Regulation of IFNG signaling
WikiPathways Type II interferon signaling (IFNG)
Senescence and Autophagy in Cancer
TGF Beta Signaling Pathway
Cytokines and Inflammatory Response
Hypertrophy Model
Inflammatory Response Pathway
Aryl Hydrocarbon Receptor Pathway
IL1 and megakaryotyces in obesity
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Spinal Cord Injury
Allograft Rejection
Interferon gamma signaling
Proteasome Degradation
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 548727Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028077)
Ref 532955Pharmacokinetic and pharmacodynamic relationship of AMG 811, an anti-IFN-gamma IgG1 monoclonal antibody, in patients with systemic lupus erythematosus. Pharm Res. 2015 Feb;32(2):640-53.

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