Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06DYN
|
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| Former ID |
DIB019883
|
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| Drug Name |
FTY720-phosphate
|
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| Synonyms |
FTY720-P; FTY-P; fingolimod phosphate
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [539941] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C19H34NO5P
|
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| InChI |
InChI=1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)
|
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| InChIKey |
LRFKWQGGENFBFO-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Sphingosine 1-phosphate receptor 5 | Target Info | Agonist | [526947] | |
| Sphingosine-1-phosphate receptor-3 | Target Info | Agonist | [526947] | ||
| S1P4 receptor | Target Info | Agonist | [526319] | ||
| Sphingosine 1-phosphate receptor 1 | Target Info | Agonist | [526319] | ||
| Pathway Interaction Database | S1P4 pathway | ||||
| S1P5 pathway | |||||
| Sphingosine 1-phosphate (S1P) pathways1p_s1p3_pathway:S1P3 pathway | |||||
| Sphingosine 1-phosphate (S1P) pathwayfcer1pathway:Fc-epsilon receptor I signaling in mast cells | |||||
| S1P3 pathway | |||||
| S1P1 pathway | |||||
| Sphingosine 1-phosphate (S1P) pathway | |||||
| PDGFR-beta signaling pathway | |||||
| References | |||||
| Ref 526319 | The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002 Jun 14;277(24):21453-7. Epub 2002 Apr 19. | ||||
| Ref 526947 | Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther. 2004 May;309(2):758-68. Epub 2004 Jan 27. | ||||
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