Drug General Information
Drug ID
D06DGY
Former ID
DIB018058
Drug Name
(-)-N-porphynorapomorphine
Synonyms
(-)-N-porphynorapomorphine; n-propylapomorphine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543334]
Structure
Download
2D MOL
Formula
C19H21NO2
InChI
InChI=1S/C19H21NO2/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14/h3-7,15,21-22H,2,8-11H2,1H3/t15-/m1/s1
InChIKey
BTGAJCKRXPNBFI-OAHLLOKOSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [533725]
D(3) dopamine receptor Target Info Agonist [533725]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 543334(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 969).
Ref 533725A functional test identifies dopamine agonists selective for D3 versus D2 receptors. Neuroreport. 1995 Jan 26;6(2):329-32.

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