Drug Information

Drug General Information
Drug ID
D06DET
Former ID
DNC000164
Drug Name
AE-3763
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 1 [547367]
Structure
Download
2D MOL

3D MOL
Formula
C23H35N3O3
Canonical SMILES
CC(C)C1=NN2C=CC=CC2=C1C(=O)C(C)C.C1CCC(CC1)(CC(=O)O)CN
InChI
1S/C14H18N2O.C9H17NO2/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13;10-7-9(6-8(11)12)4-2-1-3-5-9/h5-10H,1-4H3;1-7,10H2,(H,11,12)
InChIKey
GTYTZCYUQFEJFM-UHFFFAOYSA-N
CAS Number
CAS 50847-11-5
PubChem Compound ID
24795102
PubChem Substance ID
49738855, 134339033, 134339676
SuperDrug ATC ID
R03DC04
SuperDrug CAS ID
cas=050847115
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [535494]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 547367Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015539)
Ref 535494Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.

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