| Drug General Information |
| Drug ID |
D06BLF
|
| Former ID |
DNC007007
|
| Drug Name |
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H12Br4
|
| Canonical SMILES |
C1CC(C(CC1C(CBr)Br)Br)Br
|
| InChI |
1S/C8H12Br4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h5-8H,1-4H2
|
| InChIKey |
PQRRSJBLKOPVJV-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Androgen receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| mRNA of androgen receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Oocyte meiosis
|
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Pathways in cancer
|
|
Prostate cancerhsa04114:Oocyte meiosis
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Prostate cancer
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NetPath Pathway
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EGFR1 Signaling Pathway
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AndrogenReceptor Signaling Pathway
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FSH Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
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FSH Signaling Pathway
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Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Coregulation of Androgen receptor activity
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Regulation of Androgen receptor activity
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Nongenotropic Androgen signaling
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Regulation of nuclear beta catenin signaling and target gene transcription
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FOXA1 transcription factor network
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Notch-mediated HES/HEY networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
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Notch-mediated HES/HEY network
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Reactome
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Nuclear Receptor transcription pathway
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Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-383280:Nuclear Receptor transcription pathway
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Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
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WikiPathways
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SIDS Susceptibility Pathways
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Integrated Pancreatic Cancer Pathway
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Prostate Cancer
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Integrated Breast Cancer Pathway
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Nuclear Receptors
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Androgen receptor signaling pathwayWP706:SIDS Susceptibility Pathways
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Androgen receptor signaling pathway
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| References |
| REF 1 | J Med Chem. 2006 Dec 14;49(25):7366-72.Identification of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane as an androgen agonist. |
|---|
