Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06BFP
|
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| Former ID |
DNC003896
|
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| Drug Name |
CGS-17867A
|
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| Drug Type |
Small molecular drug
|
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| Indication | Alcohol use disorders [ICD9: 303; ICD10:F10.2] | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C16H14ClN3O
|
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| Canonical SMILES |
C1CCC2=NC=C3C(=C2C1)NN(C3=O)C4=CC=C(C=C4)Cl.Cl
|
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| InChI |
1S/C16H14ClN3O.ClH/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20;/h5-9,19H,1-4H2;1H
|
||||
| InChIKey |
XPOZEMPUASVHEQ-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [2] | |
| Gamma-aminobutyric-acid receptor alpha-2 subunit | Target Info | Inhibitor | [2] | ||
| Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | |||||
| GABAergic synapse | |||||
| Morphine addiction | |||||
| Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction | |||||
| Nicotine addiction | |||||
| Reactome | Ligand-gated ion channel transport | ||||
| GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport | |||||
| GABA A receptor activation | |||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Iron uptake and transport | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000696) | ||||
| REF 2 | Bioorg Med Chem Lett. 2004 Jul 5;14(13):3441-4.2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor. | ||||
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