Drug Information
Drug General Information | |||||
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Drug ID |
D05YUK
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Former ID |
DIB009788
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Drug Name |
FOROPAFANT
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Synonyms |
SR-27417; Foropafant < Prop INN >; 2-[N-[2-(Dimethylamino)ethyl]-N-(3-pyridylmethyl)amino]-4-(2,4,6-triisopropylphenyl)thiazole
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C28H40N4S
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InChI |
InChI=1S/C28H40N4S/c1-19(2)23-14-24(20(3)4)27(25(15-23)21(5)6)26-18-33-28(30-26)32(13-12-31(7)8)17-22-10-9-11-29-16-22/h9-11,14-16,18-21H,12-13,17H2,1-8H3
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InChIKey |
VVBFISAUNSXQGZ-UHFFFAOYSA-N
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CAS Number |
CAS 136468-36-5
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PubChem Compound ID | |||||
PubChem Substance ID |
7980658, 10238464, 12014626, 14931747, 29300264, 52627176, 57339460, 85209765, 99222795, 104408164, 124958916, 126434302, 126591593, 129531257, 135075012, 135651077, 160838918, 162159535, 163099178, 163403181, 163846298, 163906038, 164779918, 170558734, 179149864, 184526978, 184547726, 198979497, 202819982, 204364912, 223536043, 223704937, 232805676, 252215439, 252268280, 252496134
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Target and Pathway | |||||
Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [525756], [528090], [531635] | |
NetPath Pathway | IL5 Signaling Pathway | ||||
Leptin Signaling Pathway | |||||
References | |||||
Ref 539165 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1856). | ||||
Ref 545088 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002078) | ||||
Ref 525756 | In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. Vet Res. 2000 Mar-Apr;31(2):267-72. | ||||
Ref 528090 | Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51. | ||||
Ref 531635 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. |
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