TTD | Drug: D05WYN

Drug General Information
Drug ID	D05WYN
Former ID	DNC005761
Drug Name	4-(5-Morpholin-4-yl-pentyl)-2H-phthalazin-1-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527682]
Structure		Download 2D MOL 3D MOL
Formula	C17H23N3O2
Canonical SMILES	C1COCCN1CCCCCC2=NNC(=O)C3=CC=CC=C32
InChI	1S/C17H23N3O2/c21-17-15-7-4-3-6-14(15)16(18-19-17)8-2-1-5-9-20-10-12-22-13-11-20/h3-4,6-7H,1-2,5,8-13H2,(H,19,21)
InChIKey	OSFRDFHBAQDMGC-UHFFFAOYSA-N
PubChem Compound ID	44403402
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Inhibitor	[527682]
KEGG Pathway	Base excision repair
KEGG Pathway	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 527682	Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5.4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.
Ref 527682	Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5.4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.

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Drug Information