Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05WPQ
|
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| Former ID |
DNC000364
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| Drug Name |
BW A4C
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| Drug Type |
Small molecular drug
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| Indication | Arthritis [ICD9: 710-719; ICD10:M00-M25] | Terminated | [544587] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C17H17NO3
|
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| Canonical SMILES |
CC(=O)N(CC=CC1=CC(=CC=C1)OC2=CC=CC=C2)O
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| InChI |
1S/C17H17NO3/c1-14(19)18(20)12-6-8-15-7-5-11-17(13-15)21-16-9-3-2-4-10-16/h2-11,13,20H,12H2,1H3/b8-6+
|
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| InChIKey |
CEUDWZXMLMKPNN-SOFGYWHQSA-N
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| CAS Number |
CAS 106328-57-8
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Arachidonate 5-lipoxygenase | Target Info | Inhibitor | [536189], [536518], [537431] | |
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| References | |||||
| Ref 536189 | Tumour necrosis factor production in a rat airpouch model of inflammation: role of eicosanoids. Agents Actions. 1991 Mar;32(3-4):289-94. | ||||
| Ref 536518 | Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99. | ||||
| Ref 537431 | Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas. Oncogene. 2009 Jul 23;28(29):2690-6. Epub 2009 Jun 8. | ||||
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