| Drug General Information |
| Drug ID |
D05UUW
|
| Former ID |
DNC011632
|
| Drug Name |
1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C19H20N2O
|
| Canonical SMILES |
CN1CCN(CC1)C2=CC3=CC=CC=C3OC4=CC=CC=C42
|
| InChI |
1S/C19H20N2O/c1-20-10-12-21(13-11-20)17-14-15-6-2-4-8-18(15)22-19-9-5-3-7-16(17)19/h2-9,14H,10-13H2,1H3
|
| InChIKey |
ZCCUIFWJESTQQQ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
D(1B) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| D(3) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
| D(4) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
| Dopamine D1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
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|
cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04015:Rap1 signaling pathway
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Gap junction
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Dopaminergic synapse
|
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Parkinson's disease
|
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Cocaine addiction
|
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Alcoholismhsa04080:Neuroactive ligand-receptor interaction
|
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Dopaminergic synapsehsa04020:Calcium signaling pathway
|
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Amphetamine addiction
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Morphine addiction
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Alcoholism
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PANTHER Pathway
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Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway
|
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PathWhiz Pathway
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Dopamine Activation of Neurological Reward System
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Reactome
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Dopamine receptors
|
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G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
|
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
|
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G alpha (s) signalling events
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WikiPathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
|
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Genes and (Common) Pathways Underlying Drug Addiction
|
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Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
|
| References |
| REF 1 | J Med Chem. 1982 Jul;25(7):855-8.Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. |
|---|
