Drug Information

Drug General Information
Drug ID
D05UGJ
Former ID
DCL000017
Drug Name
XL844
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 1 [521743]
Therapeutic Class
Anticancer Agents
Company
Exelixis
Structure
Download
2D MOL

3D MOL
Formula
C14H17N5O2
Canonical SMILES
C1=CC=C(C(=C1)NC(=O)NC2=NC=CN=C2)OCCCN
InChI
1S/C14H17N5O2/c15-6-3-9-21-12-5-2-1-4-11(12)18-14(20)19-13-10-16-7-8-17-13/h1-2,4-5,7-8,10H,3,6,9,15H2,(H2,17,18,19,20)
InChIKey
UVSSZSQSZGKMAL-UHFFFAOYSA-N
PubChem Compound ID
10016910
PubChem Substance ID
14997810, 22447341, 44109005, 74454073, 134338730, 139620218, 142994715, 239497091, 247769857
Target and Pathway
Target(s) Serine/threonine-protein kinase Chk2 Target Info Modulator [1572591]
Serine/threonine-protein kinase Chk1 Target Info Modulator [1572591]
KEGG Pathway Cell cycle
p53 signaling pathway
HTLV-I infectionhsa04110:Cell cycle
HTLV-I infection
Viral carcinogenesis
Pathway Interaction Database ATM pathway
FOXM1 transcription factor network
p53 pathway
PLK3 signaling eventsfanconi_pathway:Fanconi anemia pathway
p73 transcription factor network
ATR signaling pathway
Circadian rhythm pathway
Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25AR-HSA-176187:Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
WikiPathways DNA Damage Response
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell Cycle
miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
Signaling by SCF-KIT
Retinoblastoma (RB) in Cancer
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage Response
References
Ref 521743ClinicalTrials.gov (NCT00234481) Safety Study of XL844 in Subjects With Chronic Lymphocytic Leukemia. U.S. National Institutes of Health.
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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