Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05TNK
|
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| Former ID |
DCL000824
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| Drug Name |
GSK372475
|
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| Drug Type |
Small molecular drug
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| Indication | Attention deficit hyperactivity disorder; Severe mood disorders [ICD9: 296, 314.00, 314.01; ICD10:F30-F39, F90] | Discontinued in Phase 2 | [1] | ||
| Company |
GSK; NeuroSearch
|
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| Structure |
|
Download2D MOL |
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| Formula |
C15H19Cl2NO
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| Canonical SMILES |
COCC1C2CCC(N2)CC1C3=CC(=C(C=C3)Cl)Cl
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| InChI |
1S/C15H19Cl2NO/c1-19-8-12-11(7-10-3-5-15(12)18-10)9-2-4-13(16)14(17)6-9/h2,4,6,10-12,15,18H,3,5,7-8H2,1H3/t10-,11+,12+,15+/m0/s1
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| InChIKey |
FPTPUYCHSWIWIB-FUTJPDQTSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Dopamine reuptake | Target Info | Inhibitor | [2] | |
| Sodium-dependent noradrenaline transporter | Target Info | Inhibitor | [2] | ||
| Sodium-dependent serotonin transporter | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | Serotonergic synapse | ||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway | ||||
| 5HT2 type receptor mediated signaling pathway | |||||
| 5HT3 type receptor mediated signaling pathway | |||||
| 5HT4 type receptor mediated signaling pathway | |||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | ||||
| WikiPathways | Monoamine Transport | ||||
| NRF2 pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport | |||||
| SIDS Susceptibility Pathways | |||||
| Synaptic Vesicle Pathway | |||||
| Serotonin Transporter Activity | |||||
| References | |||||
| REF 1 | Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder. Drug Des Devel Ther. 2014 Dec 1;8:2321-32. | ||||
| REF 2 | Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. | ||||
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