Drug General Information
Drug ID	D05THI
Former ID	DNC005270
Drug Name	4-Chloro-N-(3-chloro-benzoyl)-benzenesulfonamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527245]
Structure		Download 2D MOL 3D MOL
Formula	C13H9Cl2NO3S
Canonical SMILES	C1=CC(=CC(=C1)Cl)C(=O)NS(=O)(=O)C2=CC=C(C=C2)Cl
InChI	1S/C13H9Cl2NO3S/c14-10-4-6-12(7-5-10)20(18,19)16-13(17)9-2-1-3-11(15)8-9/h1-8H,(H,16,17)
InChIKey	OPPZHIMBWGDCCT-UHFFFAOYSA-N
PubChem Compound ID	11174891
Target and Pathway
Target(s)	Vascular endothelial growth factor receptor 3	Target Info	Inhibitor	[527245]
	mRNA of VEGFR1	Target Info	Inhibitor	[527245]
	Vascular endothelial growth factor receptor 2	Target Info	Inhibitor	[527245]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	PI3K-Akt signaling pathway
	Focal adhesionhsa04014:Ras signaling pathway
	HIF-1 signaling pathway
	Endocytosis
	Focal adhesion
	Transcriptional misregulation in cancer
	Rheumatoid arthritishsa04014:Ras signaling pathway
	VEGF signaling pathway
	Proteoglycans in cancer
NetPath Pathway	TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Angiogenesis
	VEGF signaling pathway
Pathway Interaction Database	VEGF and VEGFR signaling network
	VEGFR3 signaling in lymphatic endotheliumglypican_1pathway:Glypican 1 network
	HIF-2-alpha transcription factor network
	S1P3 pathway
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2hif2pathway:HIF-2-alpha transcription factor network
	Beta3 integrin cell surface interactions
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	Integrins in angiogenesis
	Signaling events mediated by VEGFR1 and VEGFR2
	Notch-mediated HES/HEY network
Reactome	VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerization
	Integrin cell surface interactions
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated cell proliferation
WikiPathways	Signaling by VEGFWP306:Focal Adhesion
	Signaling by VEGF
	AngiogenesisWP306:Focal Adhesion
	Nifedipine Activity
	Cardiac Progenitor Differentiation
	Angiogenesis
References
Ref 527245	J Med Chem. 2004 Oct 21;47(22):5367-80.Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents.
Ref 527245	J Med Chem. 2004 Oct 21;47(22):5367-80.Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents.

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