| Drug General Information |
| Drug ID |
D05SWY
|
| Former ID |
DNC005858
|
| Drug Name |
3-Dimethylaminomethyl-1H-indol-4-ol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H14N2O
|
| Canonical SMILES |
CN(C)CC1=CNC2=C1C(=CC=C2)O
|
| InChI |
1S/C11H14N2O/c1-13(2)7-8-6-12-9-4-3-5-10(14)11(8)9/h3-6,12,14H,7H2,1-2H3
|
| InChIKey |
YJJMKVPZBCHYHD-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 2B receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 2C receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
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Serotonergic synapse
|
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Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
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Inflammatory mediator regulation of TRP channels
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PANTHER Pathway
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5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
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Reactome
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Serotonin receptors
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (q) signalling events
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WikiPathways
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
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SIDS Susceptibility Pathways
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GPCR downstream signaling
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GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9.SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. |
|---|
