Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05SUA
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| Former ID |
DIB010478
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| Drug Name |
A-798
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| Synonyms |
A-429; A-655; A-665798; A-748; A-761; A-780748; A-798; MCHR-1 antagonists (obesity); Melanin concentrating hormone-1 receptor antagonists, Abbott; MCH-1 antagonists (obesity), Abbott; MCHR-1 antagonists (obesity), Abbott
|
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| Indication | Obesity [ICD9: 278; ICD10:E66] | Terminated | [1] | ||
| Company |
Abbott Laboratories
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(cc(=O)c2cc(ccc2o1)F)C(=O)NC1CCN(CC1)Cc1cc2OCOc2cc1
|
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| Target and Pathway | |||||
| Target(s) | Melanin-concentrating hormone receptor 1 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021828) | ||||
| REF 2 | Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function. Endocrinology. 2012 Dec;153(12):6145-54. | ||||
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