Drug Information
Drug General Information | |||||
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Drug ID |
D05SFA
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Former ID |
DIB019133
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Drug Name |
cicaprost
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Synonyms |
ZK 96480; ZK-96480
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539218] | ||
Structure |
Download2D MOL |
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Formula |
C22H30O5
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InChI |
InChI=1S/C22H30O5/c1-3-4-5-6-15(2)20(23)8-7-18-19-12-16(9-10-27-14-22(25)26)11-17(19)13-21(18)24/h9,15,17-21,23-24H,3,6,10-14H2,1-2H3,(H,25,26)/b16-9+/t15-,17-,18+,19-,20+,21+/m0/s1
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InChIKey |
ARUGKOZUKWAXDS-SEWALLKFSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Prostacyclin receptor | Target Info | Agonist | [534478] | |
Prostaglandin E2 receptor, EP1 subtype | Target Info | Agonist | [525673] | ||
Prostaglandin E2 receptor EP3 subtype | Target Info | Agonist | [534478] | ||
Prostaglandin E2receptor, EP2 subtype | Target Info | Agonist | [534478] | ||
Prostaglandin E2 receptor, EP4 subtype | Target Info | Agonist | [525673] | ||
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
Vascular smooth muscle contraction | |||||
Platelet activationhsa04020:Calcium signaling pathway | |||||
Pathways in cancerhsa04020:Calcium signaling pathway | |||||
cAMP signaling pathway | |||||
Regulation of lipolysis in adipocytes | |||||
Pathways in cancerhsa04024:cAMP signaling pathway | |||||
Inflammatory mediator regulation of TRP channels | |||||
Renin secretion | |||||
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction | |||||
Pathways in cancer | |||||
PANTHER Pathway | PI3 kinase pathway | ||||
Pathway Interaction Database | Thromboxane A2 receptor signaling | ||||
WikiPathways | Prostaglandin Synthesis and Regulation | ||||
GPCRs, Class A Rhodopsin-like | |||||
Small Ligand GPCRs | |||||
Endothelin Pathways | |||||
Platelet homeostasis | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
Ovarian Infertility Genes | |||||
Vitamin D Receptor Pathway | |||||
GPCR downstream signaling | |||||
References | |||||
Ref 525673 | The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. | ||||
Ref 534478 | Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. |
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