Drug General Information
Drug ID
D05SFA
Former ID
DIB019133
Drug Name
cicaprost
Synonyms
ZK 96480; ZK-96480
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539218]
Structure
Download
2D MOL
Formula
C22H30O5
InChI
InChI=1S/C22H30O5/c1-3-4-5-6-15(2)20(23)8-7-18-19-12-16(9-10-27-14-22(25)26)11-17(19)13-21(18)24/h9,15,17-21,23-24H,3,6,10-14H2,1-2H3,(H,25,26)/b16-9+/t15-,17-,18+,19-,20+,21+/m0/s1
InChIKey
ARUGKOZUKWAXDS-SEWALLKFSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Prostacyclin receptor Target Info Agonist [534478]
Prostaglandin E2 receptor, EP1 subtype Target Info Agonist [525673]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [534478]
Prostaglandin E2receptor, EP2 subtype Target Info Agonist [534478]
Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [525673]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activationhsa04020:Calcium signaling pathway
Pathways in cancerhsa04020:Calcium signaling pathway
cAMP signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04024:cAMP signaling pathway
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction
Pathways in cancer
NetPath Pathway IL2 Signaling PathwayNetPath_25:FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway PI3 kinase pathway
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (q) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Gastrin-CREB signalling pathway via PKC and MAPK
Ovarian Infertility Genes
Vitamin D Receptor Pathway
GPCR downstream signaling
References
Ref 539218(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1917).
Ref 525673The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.
Ref 534478Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.

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