TTD | Drug: D05REL

Drug General Information
Drug ID	D05REL
Former ID	DIB006211
Drug Name	GR-82334
Indication	Emesis [ICD9: 787; ICD10:R11]		Terminated	[546010]
Company	Glaxo Group Research Ltd
Structure		Download 2D MOL 3D MOL
Formula	C69H91N15O16
Canonical SMILES	N1(C(=O)[C@@]2(N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](<br />NC(=O)[C@@H](NC(=O)[C@H]3N(C(=O)[C@@H](NC(=O)[C@@H](NC(<br />=O)[C@H]4NC(=O)CC4)C)CC(=O)O)CCC3)CC(=O)N)CCCCN)Cc3cccc<br />c3)Cc3ccc(cc3)O)CCC2)CC1)[C@H](C(=O)N[C@H](C(=O)N)Cc1c[<br />nH]c2c1cccc2)CC(C)C
CAS Number	CAS 129623-01-4
PubChem Compound ID	16130972
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[526764]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546010	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005872)
Ref 526764	Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci. 1992;51(26):PL277-80.

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Drug Information