Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05REL
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| Former ID |
DIB006211
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| Drug Name |
GR-82334
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| Indication | Emesis [ICD9: 787; ICD10:R11] | Terminated | [1] | ||
| Company |
Glaxo Group Research Ltd
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| Structure |
|
Download2D MOL |
|||
| Formula |
C69H91N15O16
|
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| Canonical SMILES |
N1(C(=O)[C@@]2(N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](<br />NC(=O)[C@@H](NC(=O)[C@H]3N(C(=O)[C@@H](NC(=O)[C@@H](NC(<br />=O)[C@H]4NC(=O)CC4)C)CC(=O)O)CCC3)CC(=O)N)CCCCN)Cc3cccc<br />c3)Cc3ccc(cc3)O)CCC2)CC1)[C@H](C(=O)N[C@H](C(=O)N)Cc1c[<br />nH]c2c1cccc2)CC(C)C
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| CAS Number |
CAS 129623-01-4
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Substance-P receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Measles | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Spinal Cord Injury | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005872) | ||||
| REF 2 | Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci. 1992;51(26):PL277-80. | ||||
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