Drug Information
Drug General Information | |||||
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Drug ID |
D05REB
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Former ID |
DIB005851
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Drug Name |
ZT-1
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Synonyms |
(5R,9R)-5-(5-Chloro-2-hydroxy-3-methoxybenzylideneamino)-11-ethylidene-7-methyl-1,2,5,6,9,10-hexahydro-5,9-methanocycloocta[b]pyridin-2-one; 180694-97-7
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Drug Type |
Small molecular drug
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Indication | Parkinson's disease [ICD9: 332; ICD10:G20] | Phase 1 | [532328] | ||
Structure |
Download2D MOL |
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Formula |
C23H23ClN2O3
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Canonical SMILES |
CC=C1C2CC3=C(C1(CC(=C2)C)NC=C4C=C(C=C(C4=O)OC)Cl)C=CC(=<br />O)N3
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InChI |
1S/C23H23ClN2O3/c1-4-17-14-7-13(2)11-23(17,18-5-6-21(27)26-19(18)9-14)25-12-15-8-16(24)10-20(29-3)22(15)28/h4-8,10,12,14,25H,9,11H2,1-3H3,(H,26,27)/b15-12-,17-4+
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InChIKey |
GYTJFKCCTYZWGL-WQOXWKGMSA-N
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CAS Number |
CAS 180694-97-7
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Acetylcholinesterase | Target Info | Inhibitor | [527018], [551871] | |
KEGG Pathway | Glycerophospholipid metabolism | ||||
Cholinergic synapse | |||||
Pathway Interaction Database | ATF-2 transcription factor network | ||||
PathWhiz Pathway | Phospholipid Biosynthesis | ||||
References | |||||
Ref 527018 | A sensitive method for the determination of the novel cholinesterase inhibitor ZT-1 and its active metabolite huperzine A in rat blood using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2004;18(6):651-6. | ||||
Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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