Drug Information

Drug General Information
Drug ID
D05PWX
Former ID
DIB005626
Drug Name
Sulfatinib
Synonyms
Anticancer agents, Hutchison; HMPL-012; Kinase inhibitors (cancer), Hutchison; VEGFR-1, 2, 3 and FGFR 1 inhibitor (oral, cancer), Hutchison
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [524745]
Company
Hutchison Medipharma Enterprises Ltd
Structure
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2D MOL

3D MOL
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 1 Target Info Inhibitor [550989]
Basic fibroblast growth factor receptor 1 Target Info Inhibitor [550989]
Vascular endothelial growth factor receptor 2 Target Info Inhibitor [550989]
Vascular endothelial growth factor receptor 3 Target Info Inhibitor [550989]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritishsa04010:MAPK signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Pathways in cancer
Proteoglycans in cancer
Prostate cancer
Melanoma
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
VEGF signaling pathway
Proteoglycans in cancerhsa04014:Ras signaling pathway
NetPath Pathway TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_9:TNFalpha Signaling Pathway
PANTHER Pathway Angiogenesis
FGF signaling pathwayP00005:Angiogenesis
VEGF signaling pathway
Pathway Interaction Database Glypican 1 network
HIF-2-alpha transcription factor network
S1P3 pathway
VEGF and VEGFR signaling network
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2glypican_1pathway:Glypican 1 network
Syndecan-4-mediated signaling events
N-cadherin signaling events
FGF signaling pathwayhif2pathway:HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY networkvegf_vegfr_pathway:VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endothelium
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-195399:VEGF binds to VEGFR leading to receptor dimerization
WikiPathways Focal Adhesion
Signaling by VEGF
AngiogenesisWP51:Regulation of Actin Cytoskeleton
Endochondral Ossification
MAPK Signaling Pathway
Mesodermal Commitment Pathway
Hair Follicle Development: Induction (Part 1 of 3)
Integrated Pancreatic Cancer Pathway
Signaling Pathways in Glioblastoma
Neural Crest Differentiation
Signaling by FGFRWP306:Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
AngiogenesisWP1919:Signaling by VEGF
References
Ref 524745ClinicalTrials.gov (NCT02133157) Phase I Study of Sulfatinib(HMPL-012) in Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
Ref 550989Clinical pipeline report, company report or official report of Hutchison Medi Pharma.

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