Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05NRI
|
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| Former ID |
DIB001274
|
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| Drug Name |
Ceronapril
|
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| Synonyms |
Ceranapril; SQ-29852
|
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| Drug Type |
Small molecular drug
|
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| Indication | Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] | Discontinued in Phase 2 | [1] | ||
| Company |
Bristol-Myers Squibb Co
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C21H33N2O6P
|
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| Canonical SMILES |
N1(C(=O)[C@@H](OP(=O)(O)CCCCc2ccccc2)CCCCN)[C@H](C(=O)O<br />)CCC1
|
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| CAS Number |
CAS 111223-26-8
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Angiotensin-converting enzyme | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Renin-angiotensin system | ||||
| Chagas disease (American trypanosomiasis) | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| PathWhiz Pathway | Angiotensin Metabolism | ||||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | ||||
| WikiPathways | ACE Inhibitor Pathway | ||||
| Metabolism of Angiotensinogen to Angiotensins | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000355) | ||||
| REF 2 | Radioimmunoassay for ceronapril, a new angiotensin-converting enzyme inhibitor, and its application to a pharmacokinetic study in healthy male volunteers. Ther Drug Monit. 1992 Jun;14(3):209-19. | ||||
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