Drug General Information |
Drug ID |
D05MHL
|
Former ID |
DNC010031
|
Drug Name |
Atropisomer 1
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C21H15N3O2
|
Canonical SMILES |
C1=CC=C2C(=C1)C3=C4C(=CNC4=NC=C3)C(C(=O)N2)C5=CC=C(C=C5<br />)O
|
InChI |
1S/C21H15N3O2/c25-13-7-5-12(6-8-13)18-16-11-23-20-19(16)15(9-10-22-20)14-3-1-2-4-17(14)24-21(18)26/h1-11,18,25H,(H,22,23)(H,24,26)
|
InChIKey |
LGIBDQRYOFBMTC-UHFFFAOYSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Tyrosine-protein kinase JAK3 |
Target Info |
Inhibitor |
[1]
|
Tyrosine-protein kinase JAK2 |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
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Chemokine signaling pathway
|
PI3K-Akt signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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Jak-STAT signaling pathway
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Measles
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HTLV-I infection
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Epstein-Barr virus infection
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Viral carcinogenesis
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Primary immunodeficiencyhsa04062:Chemokine signaling pathway
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Cholinergic synapse
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Prolactin signaling pathway
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Adipocytokine signaling pathway
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Leishmaniasis
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Toxoplasmosis
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Tuberculosis
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Influenza A
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Herpes simplex infection
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PANTHER Pathway
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Interleukin signaling pathway
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JAK/STAT signaling pathway
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PDGF signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
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Interferon-gamma signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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CCKR signaling map ST
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Pathway Interaction Database
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IL4-mediated signaling events
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CD40/CD40L signaling
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Signaling events mediated by TCPTP
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SHP2 signaling
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IL2-mediated signaling events
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IL2 signaling events mediated by PI3K
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IL2 signaling events mediated by STAT5endothelinpathway:Endothelins
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ErbB4 signaling events
|
GMCSF-mediated signaling events
|
IL27-mediated signaling events
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Signaling events mediated by PTP1B
|
IL12-mediated signaling events
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S1P3 pathway
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CXCR4-mediated signaling events
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IL5-mediated signaling events
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IFN-gamma pathway
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ErbB2/ErbB3 signaling events
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IL3-mediated signaling events
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IL6-mediated signaling events
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PDGFR-beta signaling pathway
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IL23-mediated signaling events
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
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Notch-mediated HES/HEY network
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Reactome
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GPVI-mediated activation cascade
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Interleukin-7 signaling
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G beta:gamma signalling through PI3Kgamma
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Interleukin-2 signaling
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RAF/MAP kinase cascade
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Interleukin receptor SHC signalingR-HSA-1059683:Interleukin-6 signaling
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MAPK3 (ERK1) activation
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MAPK1 (ERK2) activation
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Prolactin receptor signaling
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RMTs methylate histone arginines
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Interleukin-3, 5 and GM-CSF signaling
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RAF activation
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Interferon gamma signaling
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Regulation of IFNG signaling
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Interleukin receptor SHC signaling
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Growth hormone receptor signaling
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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IL-2 Signaling Pathway
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IL-4 Signaling Pathway
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Interleukin-2 signaling
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Interleukin-7 signaling
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Oncostatin M Signaling Pathway
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IL-9 Signaling Pathway
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IL-7 Signaling Pathway
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Interleukin-3, 5 and GM-CSF signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
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Type II interferon signaling (IFNG)
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Notch Signaling Pathway
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EPO Receptor Signaling
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EGF/EGFR Signaling Pathway
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IL-6 signaling pathway
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Kit receptor signaling pathway
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IL-3 Signaling Pathway
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Mesodermal Commitment Pathway
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Signaling by SCF-KIT
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Prolactin receptor signaling
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Growth hormone receptor signaling
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JAK/STAT
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BDNF signaling pathway
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Interleukin-11 Signaling Pathway
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AGE/RAGE pathway
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TSLP Signaling Pathway
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IL17 signaling pathway
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Leptin signaling pathway
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TSH signaling pathway
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Interleukin-3, 5 and GM-CSF signaling
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Interferon gamma signaling
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Factors involved in megakaryocyte development and platelet production
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IL-5 Signaling Pathway
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References |
REF 1 | J Med Chem. 2009 Dec 24;52(24):7938-41.Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole. |