Drug Information

Drug General Information
Drug ID
D05MHL
Former ID
DNC010031
Drug Name
Atropisomer 1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530583]
Structure
Download
2D MOL

3D MOL
Formula
C21H15N3O2
Canonical SMILES
C1=CC=C2C(=C1)C3=C4C(=CNC4=NC=C3)C(C(=O)N2)C5=CC=C(C=C5<br />)O
InChI
1S/C21H15N3O2/c25-13-7-5-12(6-8-13)18-16-11-23-20-19(16)15(9-10-22-20)14-3-1-2-4-17(14)24-21(18)26/h1-11,18,25H,(H,22,23)(H,24,26)
InChIKey
LGIBDQRYOFBMTC-UHFFFAOYSA-N
PubChem Compound ID
44605611
Target and Pathway
Target(s) Tyrosine-protein kinase JAK3 Target Info Inhibitor [530583]
Tyrosine-protein kinase JAK2 Target Info Inhibitor [530583]
KEGG Pathway Chemokine signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Measles
HTLV-I infection
Epstein-Barr virus infection
Viral carcinogenesis
Primary immunodeficiencyhsa04062:Chemokine signaling pathway
Cholinergic synapse
Prolactin signaling pathway
Adipocytokine signaling pathway
Leishmaniasis
Toxoplasmosis
Tuberculosis
Influenza A
Herpes simplex infection
PANTHER Pathway Interleukin signaling pathway
JAK/STAT signaling pathway
PDGF signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Interferon-gamma signaling pathway
PDGF signaling pathway
PI3 kinase pathway
CCKR signaling map ST
Pathway Interaction Database IL4-mediated signaling events
CD40/CD40L signaling
Signaling events mediated by TCPTP
SHP2 signaling
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5endothelinpathway:Endothelins
ErbB4 signaling events
GMCSF-mediated signaling events
IL27-mediated signaling events
Signaling events mediated by PTP1B
IL12-mediated signaling events
S1P3 pathway
CXCR4-mediated signaling events
IL5-mediated signaling events
IFN-gamma pathway
ErbB2/ErbB3 signaling events
IL3-mediated signaling events
IL6-mediated signaling events
PDGFR-beta signaling pathway
IL23-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
Notch-mediated HES/HEY network
Reactome GPVI-mediated activation cascade
Interleukin-7 signaling
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signalingR-HSA-1059683:Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Prolactin receptor signaling
RMTs methylate histone arginines
Interleukin-3, 5 and GM-CSF signaling
RAF activation
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin receptor SHC signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet production
WikiPathways IL-2 Signaling Pathway
IL-4 Signaling Pathway
Interleukin-2 signaling
Interleukin-7 signaling
Oncostatin M Signaling Pathway
IL-9 Signaling Pathway
IL-7 Signaling Pathway
Interleukin-3, 5 and GM-CSF signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Type II interferon signaling (IFNG)
Notch Signaling Pathway
EPO Receptor Signaling
EGF/EGFR Signaling Pathway
IL-6 signaling pathway
Kit receptor signaling pathway
IL-3 Signaling Pathway
Mesodermal Commitment Pathway
Signaling by SCF-KIT
Prolactin receptor signaling
Growth hormone receptor signaling
JAK/STAT
BDNF signaling pathway
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
TSLP Signaling Pathway
IL17 signaling pathway
Leptin signaling pathway
TSH signaling pathway
Interleukin-3, 5 and GM-CSF signaling
Interferon gamma signaling
Factors involved in megakaryocyte development and platelet production
IL-5 Signaling Pathway
References
Ref 530583J Med Chem. 2009 Dec 24;52(24):7938-41.Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.
Ref 530583J Med Chem. 2009 Dec 24;52(24):7938-41.Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.

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