TTD | Drug: D05LWE

Drug General Information
Drug ID	D05LWE
Former ID	DIB018144
Drug Name	[125I]BOP
Synonyms	[125I]-I-BOP
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539270]
Structure		Download 2D MOL
Formula	C23H29IO5
InChI	InChI=1S/C23H29IO5/c24-16-7-10-18(11-8-16)28-15-17(25)9-12-20-19(21-13-14-22(20)29-21)5-3-1-2-4-6-23(26)27/h1,3,7-12,17,19-22,25H,2,4-6,13-15H2,(H,26,27)/b3-1+,12-9+/t17-,19-,20-,21+,22-/m1/s1/i24-2
InChIKey	UYFMSCHBODMWON-ZKBYQGIHSA-N
PubChem Compound ID	23986047
PubChem Substance ID	47883264, 57388322, 135651104
Target and Pathway
Target(s)	Thromboxane A2 receptor	Target Info	Agonist	[532986]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	Prostanoid ligand receptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
	Thromboxane signalling through TP receptor
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539270	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1973).
Ref 532986	Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist. J Pharmacol Exp Ther. 1989 Nov;251(2):557-62.

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Drug Information