| Drug General Information |
| Drug ID |
D05LSY
|
| Former ID |
DIB000265
|
| Drug Name |
AKP-020
|
| Synonyms |
BEOV; Bis(ethylmaltolato)oxovanadium IV; Insulin enhancer (oral, type 2 diabetes), Akesis Pharmaceuticals
|
| Indication |
Type 2 diabetes [ICD9: 250; ICD10:E11]
|
Discontinued in Phase 2 |
[1]
|
|---|
| Company |
Akesis Pharmaceuticals
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
c1(=O)ccoc(c1[O-])CC.[V+2]=O.c1(=O)ccoc(c1[O-])CC
|
| Target and Pathway |
| Target(s) |
Insulin receptor |
Target Info |
Enhancer |
[2]
|
|---|
|
KEGG Pathway
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Ras signaling pathway
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Rap1 signaling pathway
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cGMP-PKG signaling pathway
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HIF-1 signaling pathway
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FoxO signaling pathway
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PI3K-Akt signaling pathway
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AMPK signaling pathway
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Adherens junction
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Insulin signaling pathway
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Ovarian steroidogenesis
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Type II diabetes mellitus
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Non-alcoholic fatty liver disease (NAFLD)
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Aldosterone-regulated sodium reabsorption
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NetPath Pathway
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TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
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Insulin/IGF pathway-protein kinase B signaling cascade
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PI3 kinase pathway
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Pathway Interaction Database
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Insulin Pathway
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Signaling events mediated by PTP1B
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Signaling events mediated by TCPTP
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Insulin-mediated glucose transport
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PathWhiz Pathway
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Insulin Signalling
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Leucine Stimulation on Insulin Signaling
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Reactome
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IRS activation
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Signal attenuation
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Insulin receptor signalling cascade
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Insulin receptor recycling
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WikiPathways
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DNA Damage Response (only ATM dependent)
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Insulin Signaling
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Nanoparticle triggered autophagic cell death
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AGE/RAGE pathway
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Signaling by Insulin receptor
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Folate Metabolism
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Type II diabetes mellitus
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Vitamin B12 Metabolism
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Selenium Micronutrient Network
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AMPK Signaling
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026051) |
|---|
| REF 2 | Effect of vanadium on insulin and leptin in Zucker diabetic fatty rats. Mol Cell Biochem. 2001 Feb;218(1-2):93-6. |
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